The industrialization of agriculture has increasingly prioritized profits over sustainability, threatening food sovereignty, environmental balance, and cultural heritage. For Indigenous communities, this has resulted in diminished autonomy over traditional food systems and limited opportunities for economic empowerment. The purpose of this policy brief is to provide recommendations to implement the Métis-led Myera Global Centre for Indigenous Agri-Food & Culinary Medicine’s (Global Centre) 10,000 SKU Challenge, which aims to empower Indigenous Communities and drive sustainable growth.